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, written about 1520 and published 1567 was called (English translation of title) "Diseases which lead to a Loss of Reason".
The introduction makes it clear that these are not caused by spirits, but are natural diseases.
Heinrich Kramer and Johann Sprenger's Malleus Maleficarum (The Witch Hammer), the Inquisition's guide to the diagnosis, behavior, trial, and punishment of witches, was endorsed by the Faculty of Theology at the University of Cologne.
The Malleus went through 19 editions in the next 2 centuries and provided a basis for gruesome tortures of people with deviant behavior.
This original site is now located under the the Liverpool Street railway station.
It also occurs that the frenzied poor hurt many of the persons who are out wandering through the city.
These things are known in the entire city of Valencia.
Typically, this happened at just the moment when other English hospitals were abandoning or cutting back this type of provision severely." ( at York: Pardon to Richard Sharpe of Malteby, for the death of Agnes his wife, as it appears by the record of John de Insula and the others justices of gaol delivery for York, that he was mad when he killed her.
(Calendar of Patent Rolls Reign of , later to become Bethlehem Hospital ("Bedlam"), was taken under the patronage and protection of Richard Lacer, mayor of London, and the citizens of London.
Bethlehem Hospital, or "Bedlam," later became notorious for its neglectful care of people with mental illness.